群馬大学神経科学グループ 脳研究統合フォーラム
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医学系研究科・高次機能統御系

脳神経再生医学分野

  1. Nóbrega C, Nascimento-Ferreira I, Onofre I, Albuquerque D, Hirai H, Déglon N, de Almeida LP.
    Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice.
    PLoS One 2013;8(1):e52396. (IF: 4.092)
  2. Takechi Y, Mieda T, Iizuka A, Toya S, Suto N, Takagishi K, Nakazato Y, Nakamura K, Hirai H.
    Impairment of spinal motor neurons in spinocerebellar ataxia type 1-knock-in mice.
    Neuroscience Letters 2013 Feb 22;535:67-72. (IF: 2.105)
  3. Yamaura H, Hirai H, Yanagihara D.
    Postural dysfunction in a transgenic mouse model of spinocerebellar ataxia type 3.
    Neuroscience 2013 Jul 23;243:126-35. (IF: 3.292)
  4. Mikuni T, Uesaka N, Okuno H, Hirai H, Deisseroth K, Bito H, Kano M.

    Arc/Arg3.1 is a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum.
    Neuron 2013 Jun 19;78(6):1024-35. (IF: 15.766)

  5. Nascimento-Ferreira I, Nóbrega C, Vasconcelos-Ferreira A, Onofre I, Albuquerque D, Aveleira C, Hirai H, Déglon N, Pereira de Almeida L.
    Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease.
    Brain 2013 Jul;136(Pt 7):2173-88. (IF: 9.915)
  6. Miki T, Hirai H, Takahashi T.
    Activity-dependent neurotrophin signaling underlies developmental switch of Ca2+ channel subtypes mediating neurotransmitter release.
    Journal of Neuroscience 2013 Nov 27;33(48):18755-63. (IF: 6.908)
  7. Liu HX, Lopatina O, Higashida C, Fujimoto H, Akther S, Inzhutova A, Liang M, Zhong J, Tsuji T, Yoshihara T, Sumi K, Ishiyama M, Ma WJ, Ozaki M, Yagitani S, Yokoyama S, Mukaida N, Sakurai T, Hori O, Yoshioka K, Hirao A, Kato Y, Ishihara K, Kato I, Okamoto H, Cherepanov SM, Salmina AB, Hirai H, Asano M, Brown DA, Nagano I, Higashida H.
    Displays of paternal mouse pup retrieval following communicative interaction with maternal mates
    Nature Communications 2013;4:1346 (IF: 10.015)
  8. Akther S, Korshnova N, Zhong J, Liang M, Cherepanov SM, Lopatina O, Komleva YK, Salmina AB, Nishimura T, Fakhrul AA, Hirai H, Kato I, Yamamoto Y, Takasawa S, Okamoto H, Higashida H.
    CD38 in the nucleus accumbens and oxytocin are related to paternal behavior in mice.
    Molecular Brain 2013 Sep 23;6(1):41. (IF: 4.202)
  9. Irie T, Matsuzaki Y, Sekino Y, Hirai H.
    Kv3.3 channels harboring a mutation of spinocerebellar ataxia type 13 alterexcitability and induce cell death in cultured cerebellar Purkinje cells.
    Journal of Physiology 2014 Jan 1;592(Pt 1):229-47. (IF: 4.38)

  10. Konno A, Shuvaev AN, Miyake N, Miyake K, Iizuka A, Matsuura S, Huda F, Nakamura K, Yanagi S, Shimada T, Hirai H.
    Mutant Ataxin-3 with an Abnormally Expanded Polyglutamine Chain Disrupts Dendritic Development and Metabotropic Glutamate Receptor Signaling in Mouse Cerebellar Purkinje Cells.
    Cerebellum 2014 Feb;13(1):29-41. (IF: 2.595)

  11. Matsuzaki Y, Oue M, Hirai H.
    Generation of a neurodegenerative disease mouse model using lentiviral vectors carrying an enhanced synapsin I promoter.
    Journal of Neuroscience Methods 2014 Feb 15;223:133-43. (IF: 2.114)

  12. Matsuura S, Shuvaev AN, Iizuka A, Nakamura K, Hirai H.
    Mesenchymal Stem Cells Ameliorate Cerebellar Pathology in a Mouse Model of Spinocerebellar Ataxia Type 1.
    Cerebellum  2014 Jun;13(3):323-30. (IF: 2.595)

  13. Okonogi N, Nakamura K, Suzuki Y. Suto N. Suzue K. Kaminama T. Nakano T. Hirai H.
    Cranial irradiation induces bone marrow-derived microglia in adult mouse brain tissue.
    Journal of Radiation Research 2014 Apr 4. [Epub ahead of print] (IF: 1.447)

  14. Uesaka N, Uchigashima M, Mikuni T, Nakazawa T, Nakao H, Hirai H, Aiba A, Watanabe M, Kano M.
    Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain.
    Science 2014 May 30;344(6187):1020-3. (IF: 31.03)

病態病理学分野

  1. Pierscianek D, Kim YH, Motomura K, Mittelbronn M, Paulus W, Brokinkel B, Keyvani K, Wrede K, Nakazato Y, Tanaka Y, Mariani L, Vital A, Sure U, Ohgaki H.
    MET gain in diffuse astrocytomas is associated with poorer outcome.
    Brain Pathol, 23: 13-18, 2013. (IF:4.739)
  2. Motomura K, Mittelbronn M, Paulus W, Brokinkel B, Keyvani K, Sure U, Wrede K, Nakazato Y, Tanaka Y, Nonoguchi N, Pierscianek D, Kim YH, Mariani L, Vital A, Perry A, Ohgaki H.
    PDGFRA gain in low-grade diffuse gliomas.
    J Neuropathol Exp Neurol, 72: 61-66, 2013. (IF:4.345)
  3. Oike T, Suzuki Y, Sugawara K, Shirai K, Noda SE, Tamaki T, Nagaishi M, Yokoo H, Nakazato Y, Nakano T.
    Radiotherapy plus Concomitant Adjuvant Temozolomide for Glioblastoma: Japanese Mono-Institutional Results.
    PLoS One, 8: e78943, 2013. (IF:3.730)
  4. Muragaki Y, Akimoto J, Maruyama T, Iseki H, Ikuta S, Nitta M, Maebayashi K, Saito T, Okada Y, Kaneko S, Matsumura A, Kuroiwa T, Karasawa K, Nakazato Y, Kayama T.
    Phase II clinical study on intraoperative photodynamic therapy with talaporfin sodium and semiconductor laser in patients with malignant brain tumors.
    J Neurosurg, 119: 845-852, 2013. (IF=3.148)
  5. Shibui S, Narita Y, Mizusawa J, Beppu T, Ogasawara K, Sawamura Y, Kobayashi H, Nishikawa R, Mishima K, Muragaki Y, Maruyama T, Kuratsu J, Nakamura H, Kochi M, Minamida Y, Yamaki T, Kumabe T, Tominaga T, Kayama T, Sakurada K, Nagane M, Kobayashi K, Nakamura H, Ito T, Yazaki T, Sasaki H, Tanaka K, Takahashi H, Asai A, Todo T, Wakabayashi T, Takahashi J, Takano S, Fujimaki T, Sumi M, Miyakita Y, Nakazato Y, Sato A, Fukuda H, Nomura K.
    Randomized trial of chemoradiotherapy and adjuvant chemotherapy with nimustine (ACNU) versus nimustine plus procarbazine for newly diagnosed anaplastic astrocytoma and glioblastoma (JCOG0305).
    Cancer Chemother Pharmacol, 71: 511-521, 2013. (IF:2.795)
  6. Takechi Y, Mieda T, Iizuka A, Toya S, Suto N, Takagishi K, Nakazato Y, Nakamura K, Hirai H.
    Impairment of spinal motor neurons in spinocerebellar ataxia type 1-knock-in mice.
    Neurosci Lett, 535: 67-72, 2013. (IF:2.026)
  7. Matsumura N, Yokoo H, Ying M, Wang Y, Nakazato Y.
    Olig2-positive cells in glioneuronal tumors show both glial and neuronal characters – the implication of a common progenitor cell?
    Neuropathology 33: 246-255, 2013. (IF:1.909)
  8. Nagaishi M, Yokoo H, Osawa T, Nobusawa S, Tanaka Y, Ikota H, Yoshimoto Y, Nakazato Y.
    Cytoplasmic iron deposition is associated with the expression of oxidative DNA damage marker in meningiomas.
    Neuropathology, 33: 526-532, 2013. (IF:1.909)
  9. Sasaki A, Yokoo H, Tanaka Y, Homma T, Nakazato Y, Ohgaki H.
    Characterization of microglia/macrophages in gliomas developed in S100β-v-erbB transgenic rats.
    Neuropathology, 33: 505-514, 2013. (IF:1.909)
  10. Takahashi S, Hiromura K, Tsukida M, Ohishi Y, Hamatani H, Sakurai N, Sakairi T, Ikeuchi H, Kaneko Y, Maeshima A, Kuroiwa T, Yokoo H, Aoki T, Nagata M, Nojima Y.
    Nephrotic syndrome caused by immune-mediated acquired LCAT deficiency.
    J Am Soc Nephrol, 24: 1305-1312, 2013. (IF:8.987)
  11. Nobusawa S, Suzuki A, Nagaishi M, Isoda K, Ikota H, Yokoo H, Hirato J, Nakazato Y.
    Anaplastic ependymoma with ependymoblastic multilayered rosettes.
    Hum Pathol, 44: 2597-2602, 2013. (IF:2.843)
  12. Hirose T, Nobusawa S, Nakazato Y, Sasaki A.
    A case of oligodendroglioma with prominent neuronal differentiation.
    Hum Pathol, 44: 2353-2359, 2013. (IF:2.843)
  13. Fu YJ, Taniguchi Y, Takeuchi S, Shiga A, Okamoto K, Hirato J, Nobusawa S, Nakazato Y, Kakita A, Takahashi H.
    Cerebral astroblastoma in an adult: An immunohistochemical, ultrastructural and genetic study.
    Neuropathology, 33: 312-319, 2013. (IF:1.909)
  14. Ishida A, Shibuya M, Komori T, Nobusawa S, Niimura K, Matsuo S, Hori T.
    Papillary tumor of the pineal region: a case involving isocitrate dehydrogenase (IDH) genotyping.
    Brain Tumor Pathol 30: 45-49, 2013. (IF=1.583)
  15. Shintaku M, Yoneda H, Hirato J, Nagaishi M, Okabe H.
    Gliosarcoma with ependymal and PNET-like differentiation.
    Clin Neuropathol. 2013 Nov-Dec;32(6):508-514. (IF=1.341)
  16. Hamada T, Kakizaki S, Koiso H, Irisawa H, Nobusawa S, Mori M.
    Primary hepatic mucosa-associated lymphoid tissue (MALT) lymphoma.
    Clinical Journal of Gastroenterology, 6(2): 150-155, 2013. (IF=?)
  17. Ohyama Y, Tsuchiya H, Kurosawa K, Nakano A, Arai M, Nobusawa S, Nakazato Y, Kurabayashi M.
    Pulmonary hypertension with extensive calcification in small pulmonary vessels and alveolar capillary wall in a chronic hemodialysis patient.
    Journal of Cardiology Cases, 8: e13-e16, 2013. (IF=?)

脳神経内科学分野

  1. Hayashi S, Amari M, and Okamoto K:
    Loss of calretinin- and parvalbumin-immunoreactive axons in anterolateral columns beyond the corticospinal tracts of amyotrophic lateral sclerosis spinal cords.
    J Neurol Sci., 331: 61-66, 2013. (IF: 2.243)
  2. Sakurai A, Makioka K, Fukuda T, Takatama M, and Okamoto K.
    Accumulation of phosphorylated TDP-43 in the CNS of a patient with Cockayne syndrome.
    Neuropathology., 33: 673-677, 2013. (IF: 1.909)
  3. Furuta N, Makioka K, Fujita Y, Ikeda M, Takatama M, Matsuoka M, and Okamoto K.
    Reduced expression of BTBD10 in anterior horn cells with Golgi fragmentation and pTDP-43-positive inclusions in patients with sporadic amyotrophic lateral sclerosis.
    Neuropathology., 33: 397-404, 2013. (IF: 1.909)
  4. Liu W, Yamashita T, Tian F, Morimoto N, Ikeda Y, Deguchi K, and Abe K.
    Mitochondrial fusion and fission proteins expression dynamically change in a murine model of amyotrophic lateral sclerosis.
    Curr Neurovasc Res., 10: 222-230, 2013. (IF: 2.844)
  5. Miyazaki K, Yamashita T, Morimoto N, Sato K, Mimoto T, Kurata T, Ikeda Y, and Abe K.
    Early and selective reduction of NOP56 (Asidan) and RNA processing proteins in the motor neuron of ALS model mice.
    Neurol Res., 35: 744-754, 2013. (IF: 1.182)
  6. Kurata T, Miyazaki K, Morimoto N, Kawai H, Ohta Y, Ikeda Y, and Abe K.
    Atorvastatin and pitavastatin reduce oxidative stress and improve IR/LDL-R signals in Alzheimer’s disease.
    Neurol Res., 35: 193-205, 2013. (IF: 1.182)
  7. Sato K, Morimoto N, Kurata T, Mimoto T, Miyazaki K, Ikeda Y, and Abe K.
    Impaired hypoxic sensor Siah-1, PHD3, and FIH system in spinal motor neurons of an amyotrophic lateral sclerosis mouse model.
    J Neurosci Res., 91: 285-291, 2013. (IF: 2.974)
  8. Furuta N, Makioka K, Fujita Y, and Okamoto K.
    Changes in the clinical features of amyotrophic lateral sclerosis in rural Japan.
    Intern Med., 52: 1691-1696, 2013. (IF: 0.973)
  9. Ikeda M, Yonemura K, Kakuda S, Tashiro Y, Fujita Y, Takai E, Hashimoto Y, Makioka K, Furuta N, Ishiguro K, Maruki R, Yoshida J, Miyaguchi O, Tsukie T, Kuwano R, Yamazaki T, Yamaguchi H, Amari M, Takatama M, Harigaya Y, and Okamoto K.
    Cerebrospinal fluid levels of phosphorylated tau and Aβ1-38/Aβ1-40/Aβ1-42 in Alzheimer’s disease with PS1 mutations.
    Amyloid., 20: 107-112, 2013. (IF: 4.436)
  10. Sohmiya M, Wada N, Tazawa M, Okamoto K, and Shirakura K.
    Immediate effects of physical therapy on gait disturbance and frontal assessment battery in Parkinson’s disease.
    Geriatr Gerontol Int., 13: 630-637, 2013. (IF: 2.167)
  11. Matsuzono K, Yoshiki T, Wakutani Y, Manabe Y, Yamashita T, Deguchi K, Ikeda Y, and Abe K.
    Synchronized Babinski and Chaddock signs preceded the MRI findings in a case of repetitive transient ischemic attack.
    Intern Med., 52: 2127-2129, 2013. (IF: 0.973)
  12. Matsuzono K, Ikeda Y, Deguchi S, Yamashita T, Kurata T, Deguchi K, and Abe K.
    Cerebral embolic stroke after disappearing takotsubo cardiomyopathy.
    J Stroke Cerebrovasc Dis., 22: e682-683, 2013. (IF: 1.984)
  13. Matsuzono K, Kurata T, Deguchi S, Yamashita T, Deguchi K, Ikeda Y, and Abe K.
    Two Unique Cases with Anti-GluR Antibody-Positive Encephalitis.
    Clin Med Insights Case Rep., 23: 113-117, 2013. (IF:無し)
  14. Matsuzono K, Ikeda Y, Liu W, Kurata T, Deguchi S, Deguchi K, and Abe K.
    A novel familial prion disease causing pan-autonomic-sensory neuropathy and cognitive impairment.
    Eur J Neurol., 20: e67-69, 2013. (IF: 4.162)
  15. Kono S, Deguchi K, Morimoto N, Kurata T, Yamashita T, Ikeda Y, Narai H, Manabe Y, Takao Y, Kawada S, Kashihara K, Takehisa Y, Inoue S, Kiriyama H, and Abe K.
    Intravenous thrombolysis with neuroprotective therapy by edaravone for ischemic stroke patients older than 80 years of age.
    J Stroke Cerebrovasc Dis., 22: 1175-1183, 2013. (IF: 1.984)
  16. Deguchi K, Kono S, Deguchi S, Morimoto N, Kurata T, Ikeda Y, and Abe K.
    A novel useful tool of computerized touch panel-type screening test for evaluating cognitive function of chronic ischemic stroke patients.
    J Stroke Cerebrovasc Dis., 22: e197-206, 2013. (IF: 1.984)
  17. Morimoto N, Yamashita T, Sato K, Kurata T, Ikeda Y, Kusuhara T, Murata N, and Abe K.
    Assessment of swallowing in motor neuron disease and Asidan/SCA36 patients with new methods.
    J Neurol Sci., 324: 149-155, 2013. (IF: 2.243)
  18. Ikeda Y, Ohta Y, Kurata T, Shiro Y, Takao Y, and Abe K.
    Acoustic impairment is a distinguishable clinical feature of Asidan/SCA36.
    J Neurol Sci., 324: 109-112, 2013. (IF: 2.243)

脳神経外科学分野

  1. Osawa T, Tosaka M, Nagaishi M,Yoshimoto Y.
    Factors Affecting Peritumoral Brain Edema in Meningioma: Special Histological Subtypes with Prominently Extensive Edema
    J Neurooncol, 2013; 111: 49-57. [IF 3.115]
  2. Nagaishi M, Yokoo H, Osawa T, Nobusawa S, Tanaka Y, Ikota H, Yoshimoto Y, Nakazato Y.
    Cytoplasmic iron deposition is associated with the expression of oxidative DNA damage marker in meningiomas.
    Neuropathology. 2013 Oct; 33(5):526-32. [IF 1.909]
  3. Aishima K, Yoshimoto Y.
    Screening Strategy Using Sequential Serum D-Dimer Assay for the Detection and Prevention of Venous Thromboembolism after Elective Brain Tumor Surgery
    Br J Neurosurg, 2013; 27: 348-54. [IF 0.858]
  4. Iijima K, Horiguchi K, Yoshimoto Y.
    Microvascular Decompression of the Root Emerging Zone for Hemifacial Spasm: Evaluation by Fusion Magnetic Resonance Imaging and Technical Considerations
    Acta Neurochir (Wien), 2013; 155: 855-62. [IF 1.546]
  5. Shimizu M, Imai H, Kagoshima K, Umezawa E, Shimizu T, Yoshimoto Y.
    Detection of Compression Vessels in Trigeminal Neuralgia by Surface-Rendering Three-Dimensional Reconstruction of 1.5- and 3.0-T Magnetic Resonance Imaging
    World Neurosurg, 2013; 80: 378-85. [IF 1.765]
  6. Tosaka M, Sakamoto K, Watanabe S, Yodonawa M, Kunimine H, Aishima K, Fujii T, Yoshimoto Y.
    Critical Classification of Craniostomy for Chronic Subdural Hematoma; Safer Technique for Hematoma Aspiration
    Neurol Med Chir (Tokyo), 2013 ; 53 :273-8.[ [IF 0.504]
  7. Yoshimoto Y, Tanaka Y.
    Risk Perception of Unruptured Intracranial Aneurysms
    Acta Neurochir (Wien), 2013;155 :2029-36. [IF 1.546]
  8. Ono H, Nakatomi H, Tsutsumi K, Inoue T, Teraoka A, Yoshimoto Y, Ide T, Kitanaka C, Ueki K, Imai H, Saito N.
    Symptomatic recurrence of intracranial arterial dissections: follow-up study of 143 consecutive cases and pathological investigation.
    Stroke 2013; 44: 126-31. [IF 6.158]

眼科学分野

  1. Otani T, Yamaguchi Y, Kishi S.
    Movement of intraretinal fluid from distant branch retinal vein occlusion to the submacular space. Clin Ophthalmol. 2013;7:81-6. (IF:0)
  2. Itakura H, Kishi S.
    Alterations of posterior precortical vitreous pockets with positional changes. Retina. 2013 Jul-Aug;33(7):1417-20. (IF:2.81)
  3. Itakura H, Kishi S, Li D, Akiyama H.
    Observation of posterior precortical vitreous pocket using swept-source optical coherence tomography. Invest Ophthalmol Vis Sci. 2013 May 3;54(5):3102-7. (IF:3.59)
  4. Itakura H, Kishi S.
    Evolution of vitreomacular detachment in healthy subjects. JAMA Ophthalmol. 2013 Oct;131(10):1348-52(IF:3.71)
  5. Akiyama H, Kashima T, Li D, Shimoda Y, Mukai R, Kishi S.
    Retinal ganglion cell analysis in Leber’s hereditary optic neuropathy Ophthalmology. 2013 Sep;120(9):1943-4 (IF:5.45)
  6. Sato T, Kishi S, Matsumoto H, Mukai R.
    Comparisons of outcomes with different intervals between adjunctive ranibizumab and photodynamic therapy for polypoidal choroidal vasculopathy. Am J Ophthalmol. 2013 Jul;156(1):95-105. (IF:4.22)
  7. Sato T, Kishi S, Otani T, Hashimoto H, Watanabe G.
    Modified technique for inducing posterior vitreous detachment through the posterior precortical vitreous pocket during microincision vitreous surgery with a wide-angle viewing system. Ophthalmologica. 2013;230(2):76-80. (IF:1.42)
  8. Itakura H, Kashima T, Itakura M, Akiyama H, Kishi S.
    Topical rebamipide improves lid wiper epitheliopathy. Clin Ophthalmol. 2013;7:2137-41. (IF:0)
  9. Shinohara Y, Kashima T, Akiyama H, Kishi S.
    Alteration of choroidal thickness in a case of carotid cavernous fistula: a case report and a review of the literature. SBMC Ophthalmol. 2013 Dec 5;13:75. (IF:1.44)

PAGETOP

医学系研究科・脳神経発達統御学

神経薬理学

  1. Ohara Y, Koganezawa N, Yamazaki H, Roppongi R T, Sato K, Sekino Y, Shirao T, “Early-stage development of human-induced pluripotent stem cell (hiPSC)-derived neurons” Journal of Neuroscience Research. in press (2015)

  2. Shioda N, Sawai M, Ishizuka Y, Shirao T., Fukunaga K. “Nuclear translocation of calcium/calmodulin-dependent protein kinase IIδ3 promoted by protein phosphatase-1 enhances brain-derived neurotrophic factor expression in dopaminergic neurons.” J. Biol. Chem. in press

  3. Shimizu H, Ishizuka Y, Yamazaki H, Shirao T. “Allopregnanolone increases mature excitatory synapses along dendrites via protein kinase A signaling.” Neuroscience  in press (2015)

  4. Fujieda T, Koganezawa N, Ide Y, Shirao T and Sekino Y. “An Inhibitory Pathway Controlling the Gating Mechanism of the Mouse Lateral Amygdala Revealed by Voltage-Sensitive Dye Imaging.” Neuroscience Letters 590:126-131 (2015)

  5. Shi-Qiong Xu, Simone Buraschi, Alaide Morcavallo, Marco Genua, Tomoaki Shirao, Stephen C. Peiper, Leonard G. Gomella, Ruth Birbe, Antonino Belfiore, Renato V. Iozzo and Andrea Morrione “A novel role for drebrin in regulating progranulin bioactivity in bladder cancer.” Oncotarget 10;6(13):10825-10839 (2015)

  6. Ishizuka Y, Shimizu H, Takagi E, Kato M, Yamagata H, Mikuni M, Shirao T. “Histone deacetylase mediates the decrease in drebrin cluster density induced by amyloid beta oligomers.” Neurochem Int. 76:114-121 (2014)

  7. Tanabe K, Yamazaki H, Inaguma Y, Asada A, Kimura T, Takahashi J, Taoka M, Ohshima T, Furuichi T, Isobe T, Nagata K, Shirao T,  Hisanaga S. “Phosphorylation of drebrin by cyclin-dependent kinase 5 and its role in neuronal migration.” PLoS One. 9:e92291 (2014)

  8. Ishikawa M, Shiota J, Ishibashi1 Y, Hakamata T, Shoji S, Fukuchi M, Masaaki Tsuda M, Shirao T, Sekino Y, Baraban JM and Tabuchi A. “Cellular localization and dendritic function of rat isoforms of the SRF coactivator MKL1 in cortical neurons.” NeuroReport. 25:585-592 (2014)
  9. Mizui T, Sekino Y, Yamazaki H, Ishizuka Y, Takahashi H, Kojima N, Kojima M and ShiraoT.
    “Myosin II ATPase activity mediates the long-term potentiation-induced exodus of stable F-actin bound by drebrin A from dendritic spines.” PLOS ONE.
    9(1):e85367(2014)
  10. Yamazaki H, Kojima N, Kato K, Hirose H, Iwasaki T, Mizui T, Takahashi H, Hanamura K,  RoppongiRT, KoibuchiN, SekinoY, MoriN, ShiraoT.
    “Spikar, a novel drebrin-binding protein, regulates the formation and stabilization of dendritic spines.” J Neurochem. 128:507-522 (2014)
  11. Ishikawa M, Shiota J, Ishibashi Y, Hakamata T, Shoji S, Fukuchi M, Tsuda M, Shirao T, Sekino Y, Ohtsuka T, Baraban JM, Tabuchi A.
    “Identification, expression and characterization of rat isoforms of the SRF coactivator MKL1.” FEBS Open Bio. 2013 Sep 7;3:387-93. (IF:-)
  12. Ishizuka Y, Kakiya N, Witters LA, Oshiro N, Shirao T, Nawa H, Takei N.
    “AMP-activated protein kinase counteracts brain-derived neurotrophic factor-induced mammalian target of rapamycin complex 1 signaling in neurons.” J Neurochem.
    2013 Oct;127(1):66-77 (IF: 3.973)
  13. Shirao T, González-Billault C.
    “Actin filaments and microtubules in dendritic spines.” J Neurochem. 2013 Jul;126(2):155-64. (IF: 3.973)
  14. Roppongi RT, Kojima N, Hanamura K, Yamazaki H, Shirao T.
    “Selective reduction of drebrin and actin in dendritic spines of hippocampal neurons by activation of 5-HT(2A) receptors.” Neurosci Lett. 2013 Jun 28;547:76-81. (IF: 2.026)

遺伝発達行動学

  1. Janitzky K, Peine A, Kröber A, Yanagawa Y, Schwegler H, Roskoden T. Increased CRF mRNA expression in the sexually dimorphic BNST of male but not female GAD67 mice and TMT predator odor stress effects upon spatial memory retrieval. Behav Brain Res. 2014 in press
  2. Souchet B, Guedj F, Sahún I, Duchon A, Daubigney F, Badel A, Yanagawa Y, Barallobre MJ, Dierssen M, Yu E, Herault Y, Arbones M, Janel N, Créau N, Delabar JM. Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage. Neurobiol Dis. 2014 in press
  3. Lu YC, Chen YZ, Wei YY, He XT, Li X, Hu W, Yanagawa Y, Wang W, Wu SX, Dong YL. Neurochemical properties of the synapses between the parabrachial nucleus-derived CGRP-positive axonal terminals and the GABAergic neurons in the lateral capsular division of central nucleus of amygdala. Mol Neurobiol. 2014 in press
  4. Furukawa T, Yamada J, Akita T, Matsushima Y, Yanagawa Y, Fukuda A. Roles of taurine-mediated tonic GABAA receptor activation in the radial migration of neurons in the fetal mouse cerebral cortex. Front Cell Neurosci. 8, 88, 2014
  5. Luo DS, Huang J, Dong YL, Wu ZY, Wei YY, Lu YC, Wang YY, Yanagawa Y, Wu SX, Wang W, Li YQ. Connections between EM2- and SP-containing terminals and GABAergic neurons in the mouse spinal dorsal horn. Neurol Sci. 2014 in press
  6. Kito-Shingaki A, Seta Y, Toyono T, Kataoka S, Kakinoki Y, Yanagawa Y, Toyoshima K. Expression of GAD67 and Dlx5 in the Taste Buds of Mice Genetically Lacking Mash1. Chem Senses. 39, 403-14, 2014
  7. Sandhu KV, Lang D, Müller B, Nullmeier S, Yanagawa Y, Schwegler H, Stork O. Glutamic acid decarboxylase 67 haplodeficiency impairs social behavior in mice. Genes Brain Behav. 2014 in press
  8. Phongphanphanee P, Marino RA, Kaneda K, Yanagawa Y, Munoz DP, Isa T. Distinct local circuit properties of the superficial and intermediate layers of the rodent superior colliculus. Eur J Neurosci. 2014 in press
  9. Edwards IJ, Lall VK, Paton JF, Yanagawa Y, Szabo G, Deuchars SA, Deuchars J. Neck muscle afferents influence oromotor and cardiorespiratory brainstem neural circuits. Brain Structure and Function 2014 in press
  10. Uchida T, Furukawa T, Iwata S, Yanagawa Y, Fukuda A. Selective loss of parvalbumin-positive GABAergic interneurons in the cerebral cortex of maternally stressed Gad1-heterozygous mouse offspring. Transl Psychiatry 4, e371, 2014
  11. Zhang Y, Kaneko R, Yanagawa Y, Saito Y.  The vestibulo- and preposito-cerebellar cholinergic neurons of a ChAT-tdTomato transgenic rat exhibit heterogeneous firing properties and the expression of various neurotransmitter receptors. Eur J Neurosci. 39, 1294-313, 2014
  12. Kudo T, Konno K, Uchigashima M, Yanagawa Y, Sora I, Minami M, Watanabe M. GABAergic neurons in the ventral tegmental area receive dual GABA/enkephalin-mediated inhibitory inputs from the bed nucleus of the stria terminalis. Eur J Neurosci. 2014 in press
  13. Kayakabe M, Kakizaki T, Kaneko R, Sasaki A, Nakazato Y, Shibasaki K, Ishizaki Y, Saito H, Suzuki N, Yanagawa Y. Motor dysfunction in cerebellar Purkinje cell-specific vesicular GABA transporter knockout mice. Front Cell Neurosci. 7, 286, 2014
  14. Fogarty MJ, Yanagawa Y, Obata K, Bellingham MC, Noakes P.  Genetic Absence of the Vesicular Inhibitory Amino Acid Transporter Differentially Regulates Respiratory and Locomotor Motor Neuron Development Brain Structure and Function.  in press
  15. Hosp JA, Strüber M, Yanagawa Y, Obata K, Vida I, Jonas P, Bartos M. Morpho-physiological criteria divide dentate gyrus interneurons into classes. Hippocampus 24, 189-203, 2014
  16. Stevens HE, Su T, Yanagawa Y and Vaccarino FM.
    Prenatal stress delays inhibitory neuron progenitor migration in the developing neocortex.
    Psychoneuroendocrinology, 38: 509-521, 2013. (IF:5.137)
  17. Todaka H, Tatsukawa T, Hashikawa T, Yanagawa Y, Shibuki K and Nagao S.
    G-protein coupled modulatory actions of motilin on K+ channels and postsynaptic GABA receptors in mouse medial vestibular nuclear neurons.
    Eur J Neurosci, 37: 339-350, 2013. (IF:3.753)
  18. Saito Y and Yanagawa Y.
    Ca2+-activated ion currents triggered by ryanodine receptor-mediated Ca2+ release control the firing of inhibitory neurons in the prepositus hypoglossi nucleus.
    J Neurophysiol, 109: 389-404, 2013. (IF:3.301)
  19. Osanai M, Suzuki T, Tamura A, Yonemura T, Mori I, Yanagawa Y, Yawo H and Mushiake H.
    Development of a micro-imaging probe for functional brain imaging.
    Neurosci Res, 76: 46-52, 2013. (IF:2.204)
  20. McKenna JT, Yang C, Franciosi S, Winston S, Abarr KK, Rigby MS, Yanagawa Y, McCarley RW and Brown RE.
    Distribution and intrinsic membrane properties of basal forebrain GABAergic and parvalbumin neurons in the mouse.
    J Comp Neurol, 521: 1225-1250, 2013. (IF:3.661)
  21. Aguado C, Fernández-Alacid L, Cabañero MJ, Yanagawa Y, Schilling K, Watanabe M, Fritschy JM and Luján R.
    Differential maturation of GIRK2-expressing neurons in the mouse cerebellum.
    J Chem Neuroanat, 47: 79-89, 2013. (IF:2.475)
  22. Gocho Y, Sakai A, Yanagawa Y, Suzuki H and Saitow F.
    Electrophysiological and pharmacological properties of GABAergic cells in the dorsal raphe nucleus.
    J Physiol Sci, 63: 147-154, 2013. (IF:1.089)
  23. Dimitrov EL, Yanagawa Y and Usdin TB.
    Forebrain GABAergic projections to locus coeruleus in mouse.
    J Comp Neurol, 521: 2373-97, 2013. (IF:3.661)
  24. Niquille M, Shilpi Minocha S, Hornung JP, Rufer N, Valloton D, Kessaris N, Alfonsi F, Vitalis T, Yanagawa Y, Devenoges C, Dayer A and Lebrand C.
    Two specific populations of GABAergic neurons originating from the medial and the caudal ganglionic eminences aid in proper navigation of callosal axons.
    Develop Neurobiol, 73: 647-72, 2013. (IF:4.423)
  25. Fogarty MJ, Smallcombe KL, Yanagawa Y, Obata K, Bellingham MC and Noakes PG.
    Genetic deficiency of GABA differentially regulates respiratory and non-respiratory motor neuron development.
    PLoS One, 8: e56257, 2013. (IF:3.730)
  26. Boxwell AJ, Yanagawa Y, Travers SP and Travers JB.
    The mu-opioid receptor agonist DAMGO presynaptically suppress solitary tract-evoked input neurons in the rostral solitary nucleus.
    J Neurophysiol,. 109: 2815-26, 2013. (IF:3.301)
  27. Guo N, Yoshizaki K, Kimura R, Suto F, Yanagawa Y and Osumi N.
    A sensitive period for GABAergic interneurons in the dentate gyrus in modulating sensorimotor gating.
    J Neurosci, 33: 6691-704, 2013. (IF:6.908)
  28. Arami MK, Sohya K, Sarihi A, Jiang B, Yanagawa Y and Tsumoto T.
    Reciprocal homosynaptic and heterosynaptic long-term plasticity of corticogeniculate projection neurons in layer VI of the mouse visual cortex.
    J Neurosci. 33, 7787-98, 2013. (IF:6.908)
  29. Chen T, Wang XL, Qu J, Wang W, Zhang T, Yanagawa Y, Wu SX and Li YQ.
    Neurokinin-1 receptor-expressing neurons that contain serotonin and gamma-aminobutyric acid in the rat rostroventromedial medulla are involved in pain processing.
    J Pain, 14: 778-92, 2013. (IF:3.240)
  30. Egawa K, Yamada J, Furukawa T, Yanagawa Y and Fukuda A.
    Cl- homeodynamics in gap-junction-coupled astrocytic networks on activation of GABAergic synapses.
    J Physiol, 591: 3901-17, 2013. (IF:4.380)
  31. Tomiyama K, Kato R, Hara Y, Kobayashi M, Mishina M, Yanagawa Y, Kinsella A, Koshikawa N and Waddington JL.
    Phenotypic characterization of orofacial movement topography in mutants with disruption of amino acid mechanisms: glutamate N2A/B/D [GluR1/2/4] subtypes and the GABA synthesising enzyme GAD65.
    Neuroscience, 250: 743-754, 2013. (IF:3.122)
  32. Ogiwara I, Iwasato T, Miyamoto H, Iwata R, Yamagata T, Mazaki E, Yanagawa Y, Tamamaki N, Hensch TK, Itohara S and Yamakawa K.
    Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome.
    Hum Mol Genet, 22: 4784-804, 2013. (IF:7.692)

分子細胞生物学

  1. Sadakata, T., Kakegawa, W., Shinoda, Y., Hosono, M., Katoh-Semba, R., Sekine, Y., Sato, Y., Tanaka, M., Iwasato, T., Itohara, S., Furuyama, K., Kawaguchi, Y., Ishizaki, Y., Yuzaki,, M. and Furuichi, T.
    CAPS1 deficiency perturbs dense-core vesicle trafficking and Golgi structure and reduces presynaptic release probability in the mouse brain.
    J Neurosci 33: 17326-17334 (2013). (IF:6.908)
  2. Shibasaki, K., Ishizaki, Y., Mandadi, S.
    Astrocytes functionally express TRPV2 channel.
    Biochem Biophys Res Commun 441: 327-332, (2013). (IF:2.406)
  3. Okano-Uchida,T., Naruse, M., Ikezawa, T., Shibasaki, K., and Ishizaki, Y.
    Cerebellar neural stem cells differentiate into two distinct types of astrocytes in response to CNTF and BMP2.
    Neurosci. Lett. 552: 15-20 (2013). (IF:2.026)
  4. Naruse, M., Shibasaki, K., Yokoyama, S., Kurachi, M., Ishizaki, Y.
    Dynamic Changes of CD44 Expression from Progenitors to Subpopulations of Astrocytes and Neurons in Developing Cerebellum.
    PloS one 8: e53109 (2013). (IF:3.730)

神経精神医学

  1. Sato H, Yahata N, Funane T, Takizawa R, Katura T, Atsumori H, Nishimura Y, Kinoshita A, Kiguchi M, Koizumi H, Fukuda M, Kasai K.
    A NIRS-fMIR investigation of prefrontal cortex activity during a working memory task.
    NeuroImage 83:158-173, 2013 (IF:6.252).[東京大学・日立製作所との共同研究]
  2. Takei Y, Suda M, Aoyama Y, Yamaguchi M, Sakurai N, Narita K, Fukuda M, Mikuni M.
    Temporal lobe and inferior frontal gyrus dysfunction in patients with schizophrenia during face-to-face conversation: a near-infrared spectroscopy study.
    J Psychiat Res 47:1581-9, 2013 (IF:4.066).
  3. Hirosawa R, Narumoto J, Sakai Y, Nishida S, Ishida T, Nakamae T, Takei Y, Fukui K.
    Reduced dorsolateral prefrontal cortical hemodynamic response in adult obsessive-compulsive disorder as measured by near-infrared spectroscopy during the verbal fluency task.
    Neuropsychiatr Dis Treat 9:955-62, 2013 (IF:2.000).[京都府立医大との共同研究]

麻酔神経科学

  1. Ogino Y, Kakeda T, Nakamura K, Saito S.
    Dehydration Enhances Pain-Evoked Activation in the Human Brain Compared with Rehydration.
    Anesth Analg. 2013 Dec 31. [Epub ahead of print] (IF 3.3)
  2. Saito S.
    Studies on postoperative neurological complications, particularly cognitive dysfunction.
    J Anesth. 2013 Oct;27(5):647-9. (IF 0.87)
  3. Kimura M, Hayashida K, Eisenach JC, Saito S, Obata H.
    Relief of hypersensitivity after nerve injury from systemic donepezil involves spinal cholinergic and γ-aminobutyric acid mechanisms.
    Anesthesiology. 2013 Jan;118(1):173-80. (IF 5.3)
  4. Suto T, Saito S.
    Considerations for resuscitation at high altitude in elderly and untrained populations and rescuers.
    Am J Emerg Med. 2013 Nov 12. [Epub ahead of print] (IF 1.7)
  5. Kanamoto M, Matsumoto N, Shiga T, Kunimoto F, Saito S.
    Relationship between coronary artery stenosis and cardio-ankle vascular index (CAVI) in patients undergoing cardiovascular surgery.
    J Cardiovasc Dis Res. 2013 Mar;4(1):15-9. (IF 未取得)
  6. Narahara H, Kadoi Y, Hinohara H, Kunimoto F, Saito S.
    Comparative effects of flurbiprofen and fentanyl on natural killer cell cytotoxicity, lymphocyte subsets and cytokine concentrations in post-surgical intensive care unit patients: prospective, randomized study.
    J Anesth. 2013 Oct;27(5):676-83. (IF 0.87)
  7. Kuroda M, Takemae A, Takahashi T, Mita N, Kagaya S, Miyoshi S, Kadoi Y, Saito S.
    Two- and three-dimensional transesophageal echocardiography for aortic valve aneurysms on the right coronary cusp.
    Anesth Analg. 2013 Apr;116(4):784-7. (IF 3.3)
  8. Kuroda M, Takahashi T, Mita N, Kagaya S, Miyoshi S, Saito S.
    Difficult cannulation of the coronary sinus due to a large Thebesian valve.
    Anesth Analg. 2013 Mar;116(3):563-6. (IF 3.3)
  9. Kadoi Y, Saito S, Fujita N, Mizutani A.
    Effects of balloon-induced pulsatile perfusion on postoperative short- and long-term cognitive dysfunction in diabetic patients with impaired cerebrovascular carbon dioxide reactivity.
    J Cardiothorac Vasc Anesth. 2013 Apr;27(2):238-44. (IF 1.4)

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医学系研究科・代謝機能制御系

器官機能制御学

準備中

PAGETOP

保健学研究科

生体情報検査科学講座

  1. Zen K., Guo Y., Bian Z., Lv Z., Zhu D., Ohnishi H., Matozaki T., Liu Y.
    Inflammation-induced proteolytic processing of the SIRPα cytoplasmic ITIM in neutrophils propagates a proinflammatory state
    Nature Communications. 4, 2436, 2013. (IF: 10.015)
  2. Takahashi S., Tomioka M., Hiromura K., Sakairi T., Hamatani H., Watanabe M., Ikeuchi H., Kaneko Y., Maeshima A., Aoki T., Ohnishi H., Matozaki T., Nojima Y.
    SIRPα signaling regulates podocyte structure and function
    American Journal of Physiology – Renal Physiology. 2013 Sep 15;305(6):F861-70. (IF: 3.612)
  3. Yamashita H., Kotani T., Park J.H., Murata Y., Okazawa H., Ohnishi H., Ku Y., Matozaki T. 
    Role of the protein tyrosine phosphatase Shp2 in homeostasis of the intestinal epithelium 
    PLoS One 9(3): e92904. 2014 
  4. Murata Y., Kotani T., Ohnishi H., Matozaki T. The CD47-SIRPα signaling system: its physiological roles and therapeutic application
    J. Biochem. 155(6), 335-344, 2014
  5. Koshimizu H., Takao K., Matozaki T., Ohnishi H., Miyakawa T. 
    Comprehensive behavioral analysis of Cluster of Differentiation 47 knockout mice
    PLoS ONE 9(2): e89584. 2014 
  6. Murata Y., Saito Y., Kaneko T., Kotani T., Kaneko Y., Ohnishi H., Matozaki T. 
    Autoimmune animal models in the analysis of the CD47-SIRPα signaling pathway
    Methods 65, 254-259, 2014 
  7. Mantilidewi K.I., Murata Y., Mori M., Otsubo C., Kotani T., Kusakari S., Ohnishi H., Matozaki T. 
    Shear stress-induced redistribution of Vascular Endothelial-Protein Tyrosine Phosphatase (VE-PTP) in endothelial cells and its role in cell elongation
    J. Biol. Chem. 289(19), 6451-6461, 2014 
  8. Kusakari, S., Saitow, F., Ago, Y., Shibasaki, K., Sato-Hashimoto, M., Matsuzaki, Y., Kotani T., Murata, Y., Hirai, H., Matsuda, T., Suzuki, H., Matozaki, T., Ohnishi, H. 
    Shp2 in forebrain neurons regulates synaptic plasticity, locomotion, and memory formation in mice 
    Mol. Cell. Biol. 2015 (in press)
  9. Li, X.J., Goodwin, C.B., Nabinger, S.C., Richine, B.M., Yang, Z., Hanenberg, H., Ohnishi H., Matozaki, T., Feng, G.S., and Chan, R.J. 
    Protein tyrosine phosphatase, Shp2, positively regulates macrophage oxidative burst 
    J. Biol. Chem. 290 (7): 3894-38909, 2015 

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大学院教育研究支援センター

大学院教育研究支援センター

Naoko H. Tomioka, Hiroki Yasuda, Hiroyuki Miyamoto, Minoru Hatayama, Naoko Morimura, Yoshifumi Matsumoto, Toshimitsu Suzuki, Maya Odagawa, Yuri S. Odaka, Yoshimi Iwayama, Ji Won Um, Jaewon Ko, Yushi Inoue, Sunao Kaneko, Shinichi Hirose, Kazuyuki Yamada, Takeo Yoshikawa, Kazuhiro Yamakawa, Jun Aruga

Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures.

Nature Communications, in press.

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先端科学研究指導者育成ユニット

先端医学・生命科学研究チーム

Axonal localization of Ca2+-dependent activator protein for secretion 2 is critical for subcellular locality of brain-derived neurotrophic factor and neurotrophin-3 release affecting proper development of postnatal mouse cerebellum

Tetsushi Sadakata, Wataru Kakegawa, Yo Shinoda, Mayu Hosono, Ritsuko Katoh-Semba, Yukiko Sekine, Yumi Sato, Chihiro Saruta, Yasuki Ishizaki, Michisuke Yuzaki, Masami Kojima, Teiichi Furuichi

PLoS ONE. in press.

 

Mouse Models of Mutations and Variations in Autism Spectrum Disorder-Associated Genes: Mice Expressing Caps2/Cadps2 Copy Number and Alternative Splicing Variants

Tetsushi Sadakata, Yo Shinoda, Akira Sato, Hirotoshi Iguchi, Chiaki Ishii, Makoto Matsuo, Ryosuke Yamaga, Teiichi Furuichi

International Journal of Environmental Research and Public Health. 10 (12), p6335-6353 (2013) (IF: 1.998)

 

CAPS1 deficiency perturbs dense-core vesicle trafficking and Golgi structure and reduces presynaptic release probability in the mouse brain.

Tetsushi Sadakata, Wataru Kakegawa, Yo Shinoda, Mayu Hosono, Ritsuko Katoh-Semba, Yukiko Sekine, Yumi Sato, Mika Tanaka, Takuji Iwasato, Shigeyoshi Itohara, Kenichiro Furuyama, Yoshiya Kawaguchi, Yasuki Ishizaki, Michisuke Yuzaki, Teiichi Furuichi

Journal of Neuroscience. 33 (44), p17326-17334 (2013) (IF: 6.908)

 *Both Drs. Sadakata and Furuichi are corresponding authors.

 

Animal Models of Autism Spectrum Disorder (ASD): A Synaptic-Level Approach to Autistic-Like Behavior in Mice

Yo Shinoda, Tetsushi Sadakata, Teiichi Furuichi

Experimental Animals. 62 (2), p71-78 (2013) (IF: 1.456)

 

Autistic-like behavioral phenotypes in a mouse model with copy number variation of the CAPS2/CADPS2 gene

Tetsushi Sadakata, Yo Shinoda, Megumi Oka, Yukiko Sekine, Teiichi Furuichi.

FEBS Letter. 587(1), p54-59 (2013) (IF: 3.478)

 *Both Drs. Sadakata and Furuichi are corresponding authors.

 

Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF and causes autistic-like behavior in mice.

Tetsushi Sadakata, Yo Shinoda, Megumi Oka, Yukiko Sekine, Yumi Sato, Chihiro Saruta, Hideki Miwa, Mika Tanaka, Shigeyoshi Itohara, Teiichi Furuichi

Proceedings of the National Academy of Sciences of the United States of America. 109 (51), p21104-21109 (2012) (IF: 9.737)

 *Both Drs. Sadakata and Furuichi are corresponding authors.

 

Calcium-dependent activator protein for secretion 2 (CAPS2) interacts with the class II ARF small GTPases and regulates dense-core vesicle trafficking.

Tetsushi Sadakata, Yukiko Sekine, Megumi Oka, Makoto Itakura, Masami Takahashi, Teiichi Furuichi.

FEBS Journal. 279(3), p384-394 (2012) (IF: 4.250)

 

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理工学研究院

分子化学部門

準備中

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