{"id":629,"date":"2019-07-17T20:55:31","date_gmt":"2019-07-17T11:55:31","guid":{"rendered":"http:\/\/cfns.med.gunma-u.ac.jp\/?p=629"},"modified":"2019-07-17T20:58:32","modified_gmt":"2019-07-17T11:58:32","slug":"%e8%84%b3%e7%a5%9e%e7%b5%8c%e5%86%85%e7%a7%91%e5%ad%a6%e3%82%bb%e3%83%9f%e3%83%8a%e3%83%bc%e3%81%ae%e3%81%8a%e7%9f%a5%e3%82%89%e3%81%9b","status":"publish","type":"post","link":"http:\/\/cfns.med.gunma-u.ac.jp\/?p=629","title":{"rendered":"Ranum\u6559\u6388\u306b\u3088\u308b\u8133\u795e\u7d4c\u5185\u79d1\u5b66\u30bb\u30df\u30ca\u30fc(8\/1)\u306e\u304a\u77e5\u3089\u305b"},"content":{"rendered":"<p>\u8133\u795e\u7d4c\u5185\u79d1\u5b66\u30bb\u30df\u30ca\u30fc\u306e\u304a\u77e5\u3089\u305b\u3067\u3059\u3002<\/p>\n<p>\u8b1b\u5e2b\uff1aDr. Laura P.W. Ranum<br \/>\nDirector, Center for NeuroGenetics, Professor of Molecular Genetics and Microbiology, University of Florida, USA<br \/>\n\u6f14\u984c\uff1a RAN proteins in neurologic disease: Challenges and therapeutic opportunities<br \/>\n(RAN: repeat associated non-ATG translation)<\/p>\n<p>&nbsp;<\/p>\n<p>\u65e5\u6642\uff1a\u30002019\u5e748\u67081\u65e5\uff08\u6728\uff09<br \/>\n\u6642\u9593\uff1a\u300015\uff1a00\u3000\uff5e\u300016\uff1a00<br \/>\n\u5834\u6240\uff1a\u3000\u57fa\u790e\u4e2d\u8b1b\u5802<\/p>\n<p>&nbsp;<\/p>\n<p>Ranum\u6559\u6388\u306f\u795e\u7d4c\u907a\u4f1d\u5b66\u7814\u7a76\u306e\u5206\u91ce\u3067spinocerebellar ataxia type 1 (SCA1:\u810a\u9ac4\u5c0f\u8133\u5931\u8abf\u75c71\u578b)\u3001SCA5\u3001SCA8\u3001\u7b4b\u5f37\u76f4\u6027\u30b8\u30b9\u30c8\u30ed\u30d5\u30a3\u30fc2\u578b (DM2)\u3068\u3044\u3063\u305f\u75be\u60a3\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u3092\u540c\u5b9a\u3057\u3001\u307e\u305fCAG\u3001CTG\u3084GGGGCC\u3068\u3044\u3063\u305f\u7e70\u308a\u8fd4\u3057\u914d\u5217\u306e\u4f38\u9577\u3092\u539f\u56e0\u907a\u4f1d\u5b50\u5909\u7570\u3068\u3059\u308b\u30de\u30a4\u30af\u30ed\u30b5\u30c6\u30e9\u30a4\u30c8\u30fb\u30ea\u30d4\u30fc\u30c8\u75c5\u306e\u5206\u5b50\u75c5\u614b\u7814\u7a76\u306e\u7b2c\u4e00\u4eba\u8005\u3067\u3059\u3002<\/p>\n<p>\u975e\u7ffb\u8a33\u9818\u57df\u306b\u5b58\u5728\u3059\u308b\u4f38\u9577\u30ea\u30d4\u30fc\u30c8\u7531\u6765\u306e\u8ee2\u5199\u7269\u304c\u3001AUG\u958b\u59cb\u30b3\u30c9\u30f3\u3092\u5fc5\u8981\u3068\u3057\u306a\u3044\u3067\u30a2\u30df\u30ce\u9178\u306e\u5358\u7d14\u306a\u7e70\u308a\u8fd4\u3057\u304b\u3089\u306a\u308b\u30db\u30e2\u30dd\u30ea\u30de\u30fc\u30bf\u30f3\u30d1\u30af\u3092\u5f62\u6210\u3059\u308b\u7ffb\u8a33\u306e\u5f62\u5f0f (repeat-associated non-ATG (RAN) translation) \u3092\u767a\u898b\u3057\u3001\u73fe\u5728\u3001\u8907\u6570\u306e\u30de\u30a4\u30af\u30ed\u30b5\u30c6\u30e9\u30a4\u30c8\u30fb\u30ea\u30d4\u30fc\u30c8\u75c5\u306e\u5206\u5b50\u75c5\u614b\u3068\u3057\u3066\u3001RAN translation\u3092\u4ecb\u3057\u3066\u7ffb\u8a33\u3055\u308c\u305f\u75c5\u7684\u5206\u5b50\u306b\u3088\u308b\u795e\u7d4c\u5909\u6027\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u5927\u5909\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n\u30de\u30a4\u30af\u30ed\u30b5\u30c6\u30e9\u30a4\u30c8\u30fb\u30ea\u30d4\u30fc\u30c8\u4f38\u9577\u306b\u3088\u308b\u795e\u7d4c\u30fb\u7b4b\u75be\u60a3\u306e\u75c5\u614b\u89e3\u660e\u304a\u3088\u3073\u6cbb\u7642\u3078\u5411\u3051\u305f\u6700\u5148\u7aef\u306e\u7814\u7a76\u306b\u3064\u3044\u3066\u3054\u8b1b\u6f14\u3092\u3044\u305f\u3060\u304d\u307e\u3059\u3002\u591a\u304f\u306e\u7686\u69d8\u306e\u3054\u53c2\u52a0\u3092\u6b53\u8fce\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u304a\u554f\u3044\u5408\u308f\u305b\u5148: \u6c60\u7530\u4f73\u751f\uff08\u8133\u795e\u7d4c\u5185\u79d1\u5b66\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8133\u795e\u7d4c\u5185\u79d1\u5b66\u30bb\u30df\u30ca\u30fc\u306e\u304a\u77e5\u3089\u305b\u3067\u3059\u3002 \u8b1b\u5e2b\uff1aDr. Laura P.W. Ranum Director, Center for NeuroGenetics, Professor of Molecular Genetics [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"_links":{"self":[{"href":"http:\/\/cfns.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/629"}],"collection":[{"href":"http:\/\/cfns.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/cfns.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/cfns.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"http:\/\/cfns.med.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=629"}],"version-history":[{"count":3,"href":"http:\/\/cfns.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/629\/revisions"}],"predecessor-version":[{"id":632,"href":"http:\/\/cfns.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/629\/revisions\/632"}],"wp:attachment":[{"href":"http:\/\/cfns.med.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=629"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/cfns.med.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=629"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/cfns.med.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=629"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}