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\u201cRegulation of a synaptic pathway in Autism spectrum disorders.<\/strong>\u201d<\/p>\n Reiko T. Roppongi PhD <\/p>\n Development of precise connections, known as synapses, between nerve cells is \u7686\u69d8\u306e\u3054\u53c2\u52a0\u3092\u304a\u5f85\u3061\u3057\u3066\u304a\u308a\u307e\u3059\u3002 \u3010\u65e5\u6642\/Dates\u3011 \uff16\u6708\uff13\u65e5 \uff11\uff11\uff1a\uff10\uff10~\uff11\uff12\uff1a0\uff10\u3000 3rd June. 11:00 \uff5e12:00 \u3010\u5834\u6240\/Venue\u3011 \u91cd\u7c92\u2f26\u7dda\u533b\u5b66\u30bb\u30f3\u30bf\u30fc \u30ab\u30f3\u30d5\u30a1\u30ec\u30f3\u30b9\u5ba4 \u3010\u53c2\u52a0\u8cbb\/Fee\u3011 […]<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"_links":{"self":[{"href":"http:\/\/cfns.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/624"}],"collection":[{"href":"http:\/\/cfns.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/cfns.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/cfns.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"http:\/\/cfns.med.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=624"}],"version-history":[{"count":3,"href":"http:\/\/cfns.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/624\/revisions"}],"predecessor-version":[{"id":627,"href":"http:\/\/cfns.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/624\/revisions\/627"}],"wp:attachment":[{"href":"http:\/\/cfns.med.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=624"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/cfns.med.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=624"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/cfns.med.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=624"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nResearch Associate,
\nKleysen Institute of Advanced Medicine
\nDepartment of Physiology and Pathophysiology
\nHealth Sciences Centre and University of Manitoba
\nManitoba, Canada.<\/p>\n
\nrequired for proper brain development and function. Synapse are the basic
\nfunctional units of the nervous system and are the main conduits for information
\ntransfer between nerve cells. Specialized proteins at synapses known as synapse
\norganizing proteins initiate the development of synapses and are also required for
\ntheir maintenance and function. Mutations in the genes for the synapse
\norganizing proteins can predispose individuals to a variety of neurodevelopmental
\nand psychiatric disorders such as autism, schizophrenia and intellectual disability.
\nTherefore, it is critical to understand how synapse organizing proteins function.
\nThough a large number of synapse organizing proteins have been discovered, how
\ntheir functions are controlled is poorly understood. The leucine rich repeat
\ntransmembrane (LRRTM4) and Neurexin (NRXN1-3) are strongly associated
\nwith non-syndromic autism spectrum disorders (ASD). We have discovered that
\nneurexins are modified with HS sugar chains. LRRTM4 binds to the HS chains of
\nneurexins and mediates presynaptic differentiation through neurexins. LRRTM4
\nis among the most potent excitatory synapse organizers. Mice expressing a
\nmutant form of LRRTM4 that cannot bind to neurexin show structural and
\nfunctional deficits at dentate gyrus excitatory synapses. These findings
\nunderscore the neurexin-HS-LRRTM4 trans-synaptic complex regulates
\nexcitatory synapse development and function in the mammalian brain and that
\naltering the HS modification on neurexins may alter synaptic pathways
\nassociated with ASD.
\nContact\uff1aGIAR support office Kanazawa (Ext. 8028)
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