{"id":169,"date":"2014-03-21T23:11:30","date_gmt":"2014-03-21T14:11:30","guid":{"rendered":"http:\/\/cfns.med.gunma-u.ac.jp\/?page_id=169"},"modified":"2014-05-16T09:45:35","modified_gmt":"2014-05-16T00:45:35","slug":"%e5%85%88%e7%ab%af%e5%8c%bb%e5%ad%a6%e3%83%bb%e7%94%9f%e5%91%bd%e7%a7%91%e5%ad%a6%e7%a0%94%e7%a9%b6%e3%83%81%e3%83%bc%e3%83%a0","status":"publish","type":"page","link":"http:\/\/cfns.med.gunma-u.ac.jp\/?page_id=169","title":{"rendered":"\u5148\u7aef\u533b\u5b66\u30fb\u751f\u547d\u79d1\u5b66\u7814\u7a76\u30c1\u30fc\u30e0"},"content":{"rendered":"<p>Axonal localization of Ca2+-dependent activator protein for secretion 2 is critical for subcellular locality of brain-derived neurotrophic factor and neurotrophin-3 release affecting proper development of postnatal mouse cerebellum<\/p>\n<p><span style=\"text-decoration: underline;\">Tetsushi Sadakata<\/span>, Wataru Kakegawa, Yo Shinoda, Mayu Hosono, Ritsuko Katoh-Semba, Yukiko Sekine, Yumi Sato, Chihiro Saruta, Yasuki Ishizaki, Michisuke Yuzaki, Masami Kojima, Teiichi Furuichi<\/p>\n<p><em><strong>PLoS ONE.<\/strong><\/em> in press.<\/p>\n<p>&nbsp;<\/p>\n<p>Mouse Models of Mutations and Variations in Autism Spectrum Disorder-Associated Genes: Mice Expressing Caps2\/Cadps2 Copy Number and Alternative Splicing Variants<\/p>\n<p><span style=\"text-decoration: underline;\">Tetsushi Sadakata<\/span>, Yo Shinoda, Akira Sato, Hirotoshi Iguchi, Chiaki Ishii, Makoto Matsuo, Ryosuke Yamaga, Teiichi Furuichi<\/p>\n<p><em><strong>International Journal of Environmental Research and Public Health.<\/strong><\/em> 10 (12), p6335-6353 (2013) (IF: 1.998)<\/p>\n<p>&nbsp;<\/p>\n<p>CAPS1 deficiency perturbs dense-core vesicle trafficking and Golgi structure and reduces presynaptic release probability in the mouse brain.<\/p>\n<p><span style=\"text-decoration: underline;\">Tetsushi Sadakata<\/span>, Wataru Kakegawa, Yo Shinoda, Mayu Hosono, Ritsuko Katoh-Semba, Yukiko Sekine, Yumi Sato, Mika Tanaka, Takuji Iwasato, Shigeyoshi Itohara, Kenichiro Furuyama, Yoshiya Kawaguchi, Yasuki Ishizaki, Michisuke Yuzaki, Teiichi Furuichi<\/p>\n<p><strong><em>Journal of Neuroscience.<\/em><\/strong> 33 (44), p17326-17334 (2013) (IF: 6.908)<\/p>\n<p>\u00a0*Both Drs. Sadakata and Furuichi are corresponding authors.<\/p>\n<p><!--[if gte mso 9]><xml><br \/>\n <o:OfficeDocumentSettings><br \/>\n  <o:AllowPNG\/><br \/>\n <\/o:OfficeDocumentSettings><br \/>\n<\/xml><![endif]--><\/p>\n<p>&nbsp;<\/p>\n<p>Animal Models of Autism Spectrum Disorder (ASD): A Synaptic-Level Approach to Autistic-Like Behavior in Mice<\/p>\n<p>Yo Shinoda, <span style=\"text-decoration: underline;\">Tetsushi Sadakata<\/span>, Teiichi Furuichi<\/p>\n<p><strong><em>Experimental Animals.<\/em><\/strong> 62 (2), p71-78 (2013) (IF: 1.456)<\/p>\n<p>&nbsp;<\/p>\n<p>Autistic-like behavioral phenotypes in a mouse model with copy number variation of the CAPS2\/CADPS2 gene<\/p>\n<p><span style=\"text-decoration: underline;\">Tetsushi Sadakata<\/span>, Yo Shinoda, Megumi Oka, Yukiko Sekine, Teiichi Furuichi.<\/p>\n<p><strong><em>FEBS Letter.<\/em><\/strong> 587(1), p54-59 (2013) (IF: 3.478)<\/p>\n<p>\u00a0*Both Drs. Sadakata and Furuichi are corresponding authors.<\/p>\n<p>&nbsp;<\/p>\n<p>Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF and causes autistic-like behavior in mice.<\/p>\n<p><span style=\"text-decoration: underline;\">Tetsushi Sadakata<\/span>, Yo Shinoda, Megumi Oka, Yukiko Sekine, Yumi Sato, Chihiro Saruta, Hideki Miwa, Mika Tanaka, Shigeyoshi Itohara, Teiichi Furuichi<\/p>\n<p><strong><em>Proceedings of the National Academy of Sciences of the United States of America.<\/em> <\/strong>109 (51), p21104-21109 (2012) (IF: 9.737)<\/p>\n<p>\u00a0*Both Drs. Sadakata and Furuichi are corresponding authors.<\/p>\n<p>&nbsp;<\/p>\n<p>Calcium-dependent activator protein for secretion 2 (CAPS2) interacts with the class II ARF small GTPases and regulates dense-core vesicle trafficking.<\/p>\n<p><span style=\"text-decoration: underline;\">Tetsushi Sadakata<\/span>, Yukiko Sekine, Megumi Oka, Makoto Itakura, Masami Takahashi, Teiichi Furuichi.<\/p>\n<p><strong><em>FEBS Journal.<\/em><\/strong> 279(3), p384-394 (2012) (IF: 4.250)<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Axonal localization of Ca2+-dependent activator protein for secretion 2 is critical for subcellular locality o [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":167,"menu_order":0,"comment_status":"open","ping_status":"open","template":"results03.php","meta":[],"_links":{"self":[{"href":"http:\/\/cfns.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/169"}],"collection":[{"href":"http:\/\/cfns.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/cfns.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/cfns.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/cfns.med.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=169"}],"version-history":[{"count":5,"href":"http:\/\/cfns.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/169\/revisions"}],"predecessor-version":[{"id":383,"href":"http:\/\/cfns.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/169\/revisions\/383"}],"up":[{"embeddable":true,"href":"http:\/\/cfns.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/167"}],"wp:attachment":[{"href":"http:\/\/cfns.med.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=169"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}